The Roman emperor Marcus Aurelius Antoninus was the last famous Stoic philosopher of antiquity. During the last 14 years of his life he faced one of the worst plagues in European history. The Antonine Plague, named after him, was probably caused by a strain of the smallpox virus. It’s estimated to have killed up to 5 million people, possibly including Marcus himself.
From AD166 to around AD180, repeated outbreaks occurred throughout the known world. Roman historians describe the legions being devastated, and entire towns and villages being depopulated and going to ruin. Rome itself was particularly badly affected, carts leaving the city each day piled high with dead bodies.